Ecosystems:
Zig
Ascon128a AEAD for Zig
Ascon is the winner of the NIST lightweight crypto competition, and is being standardized by NIST.
Does it make sense to use it on desktop/server-class CPUs? It does. When running WebAssembly.
On WebAssembly, it is significantly faster than ChaChaPoly, and doesn't have any of the side channels issues that AES-based ciphers commonly have.
Plus, it's small. And blessed by NIST.